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In This Issue of JAMA
Audio Highlights
Abstract Full Text
free access online only has audio
JAMA. 2024;332(5):e2318360. doi:10.1001/jama.2023.18360
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Audio: Pamrevlumab for IPF, Dapagliflozin in Critical Illness, Payer Involvement in Evidence Generation, and more
Original Investigation
Pamrevlumab for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial
GaneshRaghu,MD; LucaRicheldi,MD; Evans R.Fernández Pérez,MD; et al.
Abstract Full Text
has active quiz
JAMA. 2024;332(5):380-389. doi:10.1001/jama.2024.8693
This randomized clinical trial compares the efficacy and safety of pamrevlumab vs placebo for patients with idiopathic pulmonary fibrosis.
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Editorial
When the Third Time Is Not the Charm—Trial Outcomes in Idiopathic Pulmonary FibrosisAna C.Zamora,MD; Victor E.Ortega,MD, PhD; Eva M.Carmona,MD, PhD
JAMA
Caring for the Critically Ill Patient
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial
Lorraine B.Ware,MD; D. ClarkFiles,MD; AlphaFowler,MD; et al.
Abstract Full Text
JAMA. 2024;332(5):390-400. doi:10.1001/jama.2024.8772
This randomized trial assesses whether acetaminophen would increase the number of days alive and free of organ support to day 28 among critically ill patients with sepsis and respiratory or circulatory organ dysfunction.
Caring for the Critically Ill Patient
Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial
Caio A. M.Tavares,MD, PhD; Luciano C. P.Azevedo,MD, PhD; ÁlvaroRea-Neto,MD; et al.
Abstract Full Text
JAMA. 2024;332(5):401-411. doi:10.1001/jama.2024.10510
This randomized clinical trial assessed whether adding dapagliflozin to standard care for patients with acute organ dysfunction could reduce the composite outcome of hospital mortality, initiation of kidney replacement therapy, and length of stay compared with standard care alone.
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Editorial
Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction in Critically Ill PatientsHernandoGómez,MD, MPH; Lennie P. G.Derde,MD, PhD
JAMA
Research Letter
Acceptability of Hospital-at-Home Care and Capacity for Caregiver Burden
Melissa A.Frasco,PhD; Erin L.Duffy,PhD, MPH; ErinTrish,PhD
Abstract Full Text
JAMA. 2024;332(5):422-424. doi:10.1001/jama.2024.10035
This study surveys a representative US population about aspects of hospital-at-home care, including acceptability and willingness to perform caregiving tasks.
Special Communication
Integrating Clinical Trials and Practice
Why Evidence Generation Should Matter to Payers and How They Can Help
Ali B.Abbasi,MD; Lesley H.Curtis,PhD; Lee A.Fleisher,MD; et al.
Abstract Full Text
has active quiz has audio
JAMA. 2024;332(5):412-417. doi:10.1001/jama.2024.7616
This Special Communication discusses the current clinical trials system, examines why payers should support evidence generation, and suggests potential avenues for collaboration.
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Audio: Why Should Insurers Care About Clinical Trials?
Viewpoint
Integrating Clinical Trials and Practice
Embedding Patient and Health Care Professional Voices in Clinical Trials
Stuart G.Nicholls,PhD; Marion K.Campbell,PhD
Abstract Full Text
JAMA. 2024;332(5):365-366. doi:10.1001/jama.2024.6314
This Viewpoint discusses the need to include patient and health care professional perspectives in the design of clinical trials to improve trial features and implementation.
Integrating Clinical Trials and Practice
Cardiovascular Clinical Trials in the Asia-Pacific Region
Stephen J.Nicholls,MBBS, PhD; Carolyn S. P.Lam,MBBS, PhD; Adam J.Nelson,MBBS, MPH, MBA, PhD
Abstract Full Text
JAMA. 2024;332(5):367-368. doi:10.1001/jama.2024.6313
This Viewpoint discusses the potential challenges to the operational conduct of clinical trials in the Asia-Pacific region, where there is a high rate of cardiovascular disease, and provides possible solutions.
Rebuilding the Relative Value Unit–Based Physician Payment System
Laurence F.McMahonJr,MD, MPH; ZiruiSong,MD, PhD
Abstract Full Text
JAMA. 2024;332(5):369-370. doi:10.1001/jama.2024.8478
This Viewpoint explores the use of relative value units assigned by the Resource-Based Relative Value Scale in US physician payment systems and the need to rebuild this scale to reflect changes in modern clinical practice.
AHRQ’s Healthcare Extension Service—State-Based Solutions to Health Care Improvement
Karin VerlaineRhodes,MD, MS; Laura L.Sessums,JD, MD; R. BurciagaValdez,PhD, MHSA
Abstract Full Text
JAMA. 2024;332(5):371-372. doi:10.1001/jama.2023.23600
This Viewpoint from AHRQ describes the plan to create a national health care extension service to disseminate actionable knowledge, with a goal to reduce the gap from evidence of clinical effectiveness to clinical practice.
A Piece of My Mind
The Long Walk
Mary EllenSwee,MA, MLA, JD
Abstract Full Text
JAMA. 2024;332(5):373. doi:10.1001/jama.2024.10156
In this narrative medicine essay, a patient who has outlasted all the other patients with her diagnosis cannot explain why or how she has survived and decides to commemorate her good fortune with a long walk from her home to the hospital.
Editorial
When the Third Time Is Not the Charm—Trial Outcomes in Idiopathic Pulmonary Fibrosis
Ana C.Zamora,MD; Victor E.Ortega,MD, PhD; Eva M.Carmona,MD, PhD
Abstract Full Text
JAMA. 2024;332(5):374-376. doi:10.1001/jama.2024.8776
Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction in Critically Ill Patients
HernandoGómez,MD, MPH; Lennie P. G.Derde,MD, PhD
Abstract Full Text
JAMA. 2024;332(5):377-379. doi:10.1001/jama.2024.10171
JAMA Insights
Essential Tremor
W. JeffreyElias,MD; Binit B.Shah,MD
Abstract Full Text
has active quiz has multimedia has audio
JAMA. 2024;332(5):418-419. doi:10.1001/jama.2024.7475
This JAMA Insights discusses the diagnostic evaluation and treatment, including pharmacological, nonpharmacological, and surgical options, of essential tremor.
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Video: Essential and Parkinson Disease Tremor Examples
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Audio: Essential Tremor
JAMA Clinical Guidelines Synopsis
Perioperative Management of Antithrombotic Therapy
Maureen D.Lyons,MD; BaileyPope,MD; JasonAlexander,MD
Abstract Full Text
has active quiz
JAMA. 2024;332(5):420-421. doi:10.1001/jama.2024.5880
This JAMA Clinical Guidelines Synopsis summarizes the American College of Chest Physicians’ 2022 guideline on perioperative management of patients taking oral anticoagulation or antiplatelet therapy who are undergoing an elective surgery or procedure.
Medical News & Perspectives
AI in Medicine
Tapping AI’s Strengths—From Operating Room Safety to Wearable Device Interpretation
JenniferAbbasi; YulinHswen,ScD, MPH
Abstract Full Text
has audio
JAMA. 2024;332(5):354-358. doi:10.1001/jama.2024.0802
In this Medical News interview, Sachin Kheterpal, the University of Michigan Medical School’s associate dean for research information technology, joins JAMA Editor in Chief Kirsten Bibbins-Domingo to discuss AI’s number-crunching potential for improving patient care.
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Audio: The Future of Wearables and Mobile Devices for Patient Care
Picking the Optimal Variant to Target in Updated COVID-19 Vaccines Is Tricky
RitaRubin,MA
Abstract Full Text
has audio
JAMA. 2024;332(5):359-361. doi:10.1001/jama.2024.10992
This Medical News story discusses the makeup of this fall’s updated COVID-19 vaccines.
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Audio: July 2024 Medical News Summary
Medical News in Brief
Fraud Involving ADHD Drugs Prompts CDC Warning About Injury, Overdose
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):362. doi:10.1001/jama.2024.12229
Does Infectious Bird Flu Virus Persist After Pasteurization?
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):362. doi:10.1001/jama.2024.12230
Symptoms After COVID-19 Vaccination Tied to Higher Antibody Levels
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):362. doi:10.1001/jama.2024.12231
HHS to Fund New US Rural Medical Residency Programs
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):362. doi:10.1001/jama.2024.12232
Fasting, Meal Substitute Improved Blood Sugar More Than Diabetes Drugs
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):362-363. doi:10.1001/jama.2024.12233
Heavy Weightlifting Maintained Older People’s Long-Term Strength
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):363. doi:10.1001/jama.2024.12234
Guidelines May Fall Short as More Older Adults Live With Type 1 Diabetes
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):363. doi:10.1001/jama.2024.12235
Few Medicare Beneficiaries Receive Needed Opioid Use Disorder Meds
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):363. doi:10.1001/jama.2024.12236
Metformin Use Among Parents Doesn’t Increase Birth Defect Risk
EmilyHarris
Abstract Full Text
JAMA. 2024;332(5):363. doi:10.1001/jama.2024.12237
Poetry and Medicine
Mother, son
HaroldVan Lonkhuyzen,MD
Abstract Full Text
JAMA. 2024;332(5):429. doi:10.1001/jama.2024.8488
JAMA Revisited
Vitamin Confusion
Abstract Full Text
JAMA. 2024;332(5):430. doi:10.1001/jama.2023.18361
JAMA Patient Page
What Are Food Allergies?
RebeccaVoelker,MSJ
Abstract Full Text
free access
JAMA. 2024;332(5):434. doi:10.1001/jama.2024.6703
This JAMA Patient Page describes the causes, symptoms, risk factors, diagnosis, and treatment of food allergies.
Comment & Response
Video Laryngoscopy for Surgical Endotracheal Intubation
YuquanRao,MD; WangningShangGuan,MD, PhD; XiaocouWang,MD
Abstract Full Text
JAMA. 2024;332(5):425. doi:10.1001/jama.2024.11554
Video Laryngoscopy for Surgical Endotracheal Intubation
AlexanderAvidan,MD; CharlesWeissman,MD
Abstract Full Text
JAMA. 2024;332(5):425-426. doi:10.1001/jama.2024.11560
Video Laryngoscopy for Surgical Endotracheal Intubation
Benjamin H.Cloyd,MD, MIPH; AnaFernandez-Bustamante,MD, PhD; Michael Z.Root,MD, MBA
Abstract Full Text
JAMA. 2024;332(5):426. doi:10.1001/jama.2024.11564
Video Laryngoscopy for Surgical Endotracheal Intubation
Kuo-ChenChang,MD; Shun-FaHung,MD
Abstract Full Text
JAMA. 2024;332(5):426-427. doi:10.1001/jama.2024.11557
Video Laryngoscopy for Surgical Endotracheal Intubation
KurtRuetzler,MD; NikolaosSkubas,MD; Daniel I.Sessler,MD
Abstract Full Text
JAMA. 2024;332(5):427-428. doi:10.1001/jama.2024.11567
Correction
Nonauthor Collaborator Name Shown Incorrectly
Abstract Full Text
free access
JAMA. 2024;332(5):428. doi:10.1001/jama.2024.12247
JAMA Masthead
JAMA
Abstract Full Text
free access
JAMA. 2024;332(5):349-351. doi:10.1001/jama.2023.18359
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New Online
A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial
Original Investigation | August 7, 2024
Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues
Research Letter | August 7, 2024
Supporting Adolescents’ Desire to Quit E-Cigarettes
Editorial | August 7, 2024
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